Bioactive Nanofiber-Based Conduits in a Peripheral Nerve Gap Management—An Animal Model Study

The aim was to examine the efficiency of a scaffold made poly (L-lactic acid)-co-poly(?-caprolactone), collagen (COL), polyaniline (PANI), and enriched with adipose-derived stem cells (ASCs) as nerve conduit in rat model. P(LLA-CL)-COL-PANI optimized electrospun into tubular-shaped structure. Adipose tissue from 10 Lewis rats harvested for ASCs culture. A total 28 inbred male underwent sciatic transection excision mm trunk fragment. In Group A, gap remained untouched; B, an excised used autograft; C, stumps were secured conduit; D, ASCs. After 6 months observation, sacrificed. Gastrocnemius muscles nerves weight, histology analysis, fiber count analyses. showed advanced atrophy muscle, each intervention (B, D) prevented muscle mass decrease (p < 0.0001); however, addition decreased vs. autograft 0.05). Nerve revealed superior effect density observed groups use (D B p 0.0001, C 0.001). conduits promising results managing by decreasing atrophy.